Manchester United midfielder Mason Mount faces a fitness test on the injury that forced him off against Newcastle.
Bruno Fernandes, Kobbie Mainoo, Matthijs de Ligt and Harry Maguire will again miss out, while Amad Diallo, Noussair Mazraoui and Bryan Mbeumo are at the Africa Cup of Nations.
Wolves are without midfielder Andre, who serves a one-match suspension following his fifth booking of the season.
Yerson Mosquera should be fit after suffering from cramp against Liverpool, but Santiago Bueno is a doubt with a knock.
Players out: Man Utd – De Ligt, Fernandes, Mainoo, Maguire, Mbeumo, Amad Diallo, Mazraoui Wolves – Agbadou, Andre, Bellegarde, Chirewa, Chiwome, Munetsi, R Gomes, Toti
Doubts: Man Utd – Mount Wolves – Bueno
Key FPL notes:
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Not only has Matheus Cunha (£8.1m) registered at least eight more shots than any other player over the last four gameweeks (25), but the Manchester United forward also has attacking returns in three of his last four matches.
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United wing-back Patrick Dorgu (£4.1m) was the second-highest scoring player of Gameweek 18, with 17 points.
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Tolu Arokodare (£5.4m) has been Wolves’ highest-scoring player over the last three gameweeks (13 points), thanks to one goal, one assist and two bonus points.