Sinner continued to move through the gears after Djokovic rescued the first break point of the match, hitting with immense power and laser-like precision to get his opponent on the run.
The defending champion forced another two break points in the ninth game, leaving the crowd in disbelief when he netted a routine overhead on the first but making amends with a stunning backhand down the line on the second.
The Centre Court crowd rallied behind Djokovic, chanting the Serb’s name in the hope of stirring him to a fightback – but opportunities remained difficult to come by.
Djokovic withstood further pressure points on his serve for a 3-2 lead in the second set, but there would be no escape two games later when Sinner eventually seized his fourth break of that set with a wonderful drop shot.
Holding again to close in on victory with a two-set lead, Sinner was unrelenting as he sought to immediately crush Djokovic’s fading hopes by creating two break points in the Serb’s opening game of the third.
Djokovic delighted the crowd by saving those – and a third as Sinner continued to probe – but eventually bowed to a fourth to all but bring an end to the contest.
Maintaining a scintillating level, Sinner held off Djokovic to hold for a 3-1 lead before winning eight unanswered points across his final two service games.
Winning in two hours and 20 minutes, the match lasted just six minutes longer than Sinner’s quickest win of this year’s tournament.